Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores
نویسندگان
چکیده
منابع مشابه
Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores
5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many conventional genetic techniques and is thus challenging to probe. Here, we report a rapid solid-state nanopore assay that is capable of resolving 5 hmC with high specificity and se...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep29565